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9 GREAT TALKS ON CIRCADIAN RHYTHMS & EARLY DEVELOPMENT

Each of these talks was filmed live at our recent Activated Egg Symposium. Egg and stem cell researchers from around the world gathered to discuss the role of circadian rhythms in early human development and stem cell differentiation during this unique, one-day workshop. Gene Editing Human Embryos: Who Should Decide? Dinner Speaker: Arthur Applbaum, PhD…

Bedford Research Foundation Clinical Laboratory Testing for COVID19

Please DONATE to support this urgently needed FREE testing program. **FOR IMMEDIATE RELEASE** BEDFORD RESEARCH FOUNDATION CLINICAL LABORATORY WILL BE TESTING FOR COVID19. As part of its mission to support treatment of currently incurable diseases in communities, the Bedford Research Foundation clinical laboratory, located in Massachusetts, will begin offering a highly sensitive highly specific test…

DNA render

Gene Edits for Enhancement

Earlier this year, a Chinese scientist reported the birth of twin girls whose genomes had been modified to silence the CCR5 gene. The birth was reported to be one of a series of human embryo experiments designed to render the offspring resistant to infection by HIV.

Gene Edits for Treatment of Disease

Most scientists have applied the CRISPR/Cas system to specific tissues or to stem cells. Bedford Research scientists are applying the technology to edit B2M gene sequences in unfertilized eggs which are subsequently activated for stem cell derivation. Last year a Portland Oregon research team reported their efforts to repair a mutation in the gene MYBPC3 known to be associated with acute heart failure in young men.

Bedford Research Foundation Fact Sheet

OUR MISSION Bedford Research Foundation is a Massachusetts 501(c)(3) public charity and biomedical institute conducting stem cell and related research for diseases and conditions that are currently considered incurable. WHAT WE DO BRF conducts research in three principal areas: stem cells, prostate disease and HIV/AIDS. Stem Cells Advances in stem cell biology have put within…

Philanthropy Is The Key To Continued Progress

The average cost of each experiment is $90,000. Because much of our overhead is covered by fee-for-service laboratory tests, 92% of every dollar you donate goes directly toward these experiments. This innovative funding model allows Bedford Research scientists greater flexibility to move quickly in promising new research directions. Continued Progress requires meeting our annual funding…

Gene Edits for Research

Early gene editing experiments were accomplished by mating individuals with different traits. Two well known examples are Mendel’s famous red peas crossed to white peas to yield pink peas and Mr. Little’s Fancy Mice, bred for coat color, formed the basis of the Jackson Laboratory’s inbred mice to study genetic diseases.

New Research Program a Success in Mouse Stem Cells

Dr. Joel Lawitts microinjects CRISPR/Cas “gene editing” enzymes into mouse eggs to neutralize two genes at once: (1) the gene that leads to tissue rejection, and (2) the gene that allows HIV infection of cells. These are the first steps in generating off-the-shelf stem cells for everybody that are also resistant to HIV infection.

From the Director

The derivation of gene edited, universal, HIV-resistent human stem cells from unfertilized eggs will not be without controversy. Fortunately, we have meritorious individuals serving as our Ethics Advisory Board, our Human Subjects Committee and our Stem Cell Research Oversight Committee. Their guidance has helped us forge ahead into areas of stem cell development that larger…