A landmark early scientific work by Robert Hooke documenting microscopic observations made with magnifying lenses. Published in 1665 under the authority of the Royal Society, Micrographia helped establish microscopy as a scientific tool and introduced readers to detailed studies of insects, plants, cork, and other minute structures invisible to the naked eye.
ABSTRACT Men seeking surrogacy in the United States must undergo Food and Drug Administration (FDA)-mandated infectious disease screening within seven days of the sperm collected for fertility treatments. Travel bans imposed during the COVID19 pandemic (April 1, 2020 to March 7, 2022) did not deter 156 men from 12 countries from pursuing fatherhood by traveling…
Abstract Objective This study is to discover hormone pathways active in early cleaving human embryos. Methods A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency. Results Over half of the…
Dr. David Albertini, a distinguished figure in reproductive biology, shares his illustrious career and groundbreaking research in an engaging interview. From unraveling the intricacies of meiotic competence to pioneering advancements in oocyte cryopreservation and germline stem cell identification, this article offers a captivating glimpse into his lifelong contributions, making it a must-read for those passionate…
This is a copy of the court injunction which reverses the Obama administrations decision to allow for Stem Cell research funding, and upholds the Dicky-Wicker amendments ban on federal funding for this research.
Abstract Aneuploidy is common and may be a natural occurrence in early human embryos. Selecting against embryos containing aneuploid cells for embryo transfer has been reported to increase clinical pregnancies per transfer in some studies, but not others. Some aneuploidy is due to misallocation of chromosomes during meiosis, in either the egg or sperm, but most aneuploidy is…
Previous microarray analyses of RNAs from 8-cell (8C) human embryos revealed a lack of cell cycle check-points and overexpression of core circadian oscillators and cell cycle drivers relative to pluripotent human stem cells [human embryonic stem cells/induced pluripotent stem (hES/iPS)] and fibroblasts, suggesting growth factor independence during early cleavage stages. To explore this possibility, we queried…
Objective: To assess the accuracy of serology to predict the presence of cytomegalovirus (CMV) in semen of homosexual men without and with HIV coinfection. Results: Cytomegalovirus was detected by electron microscopy in 3 of 10 specimens examined. Forty-six (89%) of 52 HIV-infected men were seropositive for CMV by combined assay for IgG/IgM; two more (48…
Reprogramming somatic cells into pluripotent em- bryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)- ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to pro- duce human NT-ESCs have failed secondary to early embryonic arrest of SCNT…
The exchange of the oocyte’s genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient’s genome, might be useful for cell replacement. Here we report that the development of human oocytes after…