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Cytomegalovirus and human immunodeficiency virus in semen of homosexual men
| Authors | Joshua Lupton, Jack Vernamonti, Clinton McCabe, Jacob Noble, Hui Zhong Yin, Robert C. Eyre, Ann A. K |
| Title | Cytomegalovirus and human immunodeficiency virus in semen of homosexual men |
| Publication Date | February, 2014 |
| Journal, Volume | Fertility and Sterility, Volume 101, Issue 2, pages 350-358 |
| Abstract |
Objective: To assess the accuracy of serology to predict the presence of cytomegalovirus (CMV) in semen of homosexual men without and with HIV coinfection. Results: Cytomegalovirus was detected by electron microscopy in 3 of 10 specimens examined. Forty-six (89%) of 52 HIV-infected men were seropositive for CMV by combined assay for IgG/IgM; two more (48 of 52, 92%) were seropositive for CMV IgG by separate assay; 25 (48%) of the HIV-infected men had PCR-detectable CMV DNA in at least one semen specimen, 22 of whom (42%) had CMV in all specimens. Nineteen (13%) of the 150 specimens tested positive for HIV, whereas 67 (45%) tested positive for CMV; seven specimens tested positive for both CMV and HIV. Cytomegalovirus, but not HIV, detection in semen correlated with decreased CD4+ lymphocytes in peripheral blood (<700/μL) but was not accurately predicted by serology, leukocytospermia, or age. Conclusion(s): Cytomegalovirus in semen is not accurately predicted by serology. Sperm banking needs to include direct assessment of CMV in semen specimens. Strategies to eliminate CMV from semen specimens are needed to alleviate the risk of virus transmission. (Fertil Steril! 2014;101:350–8. !2014 by American Society for Reproductive Medicine.) |
| Keywords | CD4þ lymphocytes, Cytomegalovirus serology, HIV, leukocytospermia, Semen |
| Categories | Foundation Newsletters, Science Article Library |
| Link to Article | Cytomegalovirus and human immunodeficiency virus in semen of homosexual men |