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Stem Cells from Testis

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The Bedford scientists are now testing culture conditions to create the best environment to isolate and expand the testis stem cells. Currently, the tests are being done with mouse testis cells, but once the culture conditions have been perfected, the scientists will begin their first group of study patients.

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Stem Cell Research Article
  • December 15, 2011

    Victoria StaeblerOver-Regulation of Parthenotes Stifles Valuable Scientific Research
    by Sean Kealy, posted in the UPenn Law RegBlog

    A recent article in Scientific American questioned whether research on stem cell lines derived from unfertilized eggs was too tightly regulated by the federal government. Now that technology allows the creation of stem cells without fertilization, there is no question that federal laws and guidelines are overly restrictive, causing a detrimental effect on valuable scientific inquiry.

    Since 1996, Congress has included the Dickey-Wicker Amendment in the annual federal budget. This amendment was a conservative reaction to what some considered to be scientific research that showed little respect toward life.... Read More

  • Stem Cell Research Article
  • December 7, 2011

    Victoria StaeblerWhy I Support Stem Cell Research by Victoria Staebler

    My support for stem cell research has its foundation in my deep-seeded belief in reproductive rights for women. Since I came of age in the 1970’s, women’s reproductive rights and freedom have been continually eroded by federal and state legislation. That has been coupled with diminished government support and funding – ranging from access to abortion services to stem cell research. Because of that, I have volunteered time and donated money to help preserve these rights.

    But last summer, my support for stem cell research became personal. During a mugging on the Cape, my stepson was shot by the assailant, resulting in a severed spinal cord at T-5. He’s now a parapalegic... Read More

  • Stem Cell Research Article
  • November 17, 2011

    IN THE LAB

    Current Stem Cell ResearchProgress in Circadian Rhythms and Stem Cells

    BSCRF scientists have derived two unique lines of stem cells that may lead to a breakthrough in the efficiency of stem cell derivation and expansion.

    BSCRF scientists are following up their discovery that the genes that regulate the rhythms of daily life, circadian rhythm genes, may play important roles in stem cell derivation and stability in culture. Circadian rhythm genes regulate cells in the body by turning “on” and “off” over a 24-hour cycle in response to signals such as light/dark cycles, hormone pulses, and body temperature variations. Read More

  • Stem Cell Research Article
  • Current Stem Cell ResearchNovember 10, 2011

    The BSCRF Newsletter - Winter 2011

    In This Issue: Progress in Circadian Rhythms and Stem Cells, Developing the First Circadian Incubator, Doing More With Less: A Letter From the Director, Testis Project Update, The 2011 Activated Egg Symposium, Victoria Staeble Joins the Board of Trustees and more.

    Download the PDF or join the mailing list to get a hard copy delivered right to your door!

  • Stem Cell Research Article
  • embryos and parthenotes Scientific AmericaNovember 4, 2011
    "You Say Embryo, I Say Parthenote", BSCRF and the importance of parthenote stem cells reported in the November, 2011 Scientific American by Julia Galef.
  • Stem Cell Research Article
  • November 4, 2011
    The 2011 Activated Egg Symposium - Friday, November 4th!

    Learn More -- Nine amazing speakers at this year's symposium:

    Keynote: Dr. Janet Rossant, Professor of Molecular Genetics, Obstetrics and Gynaecology, University of Toronto, and Chief of Research at The Hospital for Sick Children

    Dr. Rossant is internationally recognized for her pioneering research in mouse genetics. Her major findings are related to the question of how genetically identical cells adopt distinct characteristics during embryo development.

    Dieter Egli, PhD
    New York Stem Cell Foundation
    "Egg Donation and Reprogramming after Nuclear Transfer"
    Ann Kiessling, PhD
    Harvard Medical School, and Director of the Bedford Stem Cell Research Foundation
    "Are early human embryos naturally aneuploid?"
    Rafael Fissore, PhD
    Chair of Veterinary and Animal Sciences, University of Massachusetts
    "Calcium signaling during egg maturation"
    Alex Meissner, PhD
    Harvard University, Department of Stem Cell and Regenerative Biology, Broad Institute
    "DNA Methylation Dynamics in Stem Cells and Development"
    Laura Grabel, PhD
    Professor of Biology, Wesleyan University
    "Embryonic stem cell-derived neurogenesis in vitro and in the hippocampus"
    Maya Mitalipova, PhD
    Director of Whitehead Institute's Stem Cell Facility, MIT
    "Cellular Reprogramming"
    David Keefe, MD
    Chair of Ob/Gyn at New York University School of Medicine
    "Efficient generation of pluripotent stem cells from immature oocytes"
    Chris Hempel
    Founder, Addi and Cassi Fund
    Dinner Speaker: "Regulatory hurdles to research"
  • Stem Cell Research Article
  • June 30, 2011
    Dr. Janet Rossant to be keynote at 2011 Activated Egg Symposium

    We're delighted to report that Dr. Janet Rossant, Professor of Molecular Genetics, Obstetrics and Gynaecology, University of Toronto, and Chief of Research at The Hospital for Sick Children has graciously agreed to be our keynote speaker for the 2011 Activated Egg Symposium.

    Dr. Rossant is internationally recognized for her pioneering research in mouse genetics. Her major findings are related to the question of how genetically identical cells adopt distinct characteristics during embryo development.

    In 2010, she received the Premeir's Summit Award, and they made this video:


    Janet Rossant grew up in the UK and trained at the Universities of Oxford and Cambridge. When still a graduate student, she conducted now-classic work defining cell lineages and cell fates in the early mouse embryo. (read more)

  • Stem Cell Research Article
  • May 24, 2011
    Bedford presents Post Vasectomy Semen Analysis test kit at Mass Innovation Nights

    As you may know, Bedford's laboratory helps cover some of our overhead by offering a couple unique products -- GEM and PVSA -- that were developed as by-products of our research. PVSA, the newer of the two, was launched just 18 months ago.

    PVSA is the first and only post-vasectomy test kit that provides CLIA certified laboratory results from a mail-in kit. This kit was developed using Bedford's patented specimen fixative and mail-in kits for research. The kit solves a vital problem for urologists... (read more)

  • Stem Cell Research Article
  • March 23, 2011
    Dr. Ann Kiessling recieves University of Virginia, School of Nursing first ever Alumni Achievement Award

    This award honors an alumna or alumnus who has shown superior achievement in a field other than nursing since graduating from the University of Virginia School of Nursing. It recognizes distinction in one’s field and/or contributions to another profession, business or industry, government or public service, education, science or technology, or service to humanity.

    Video: Retroviruses, Reproduction, and Regenerative Medicine: The Influence of Federal Funding
  • Stem Cell Research Article
  • Feb 2, 2011
    Video! The First Five Days of a Mouse in GEM, Protein-Free Culture Medium  

    Foundation scientists are deriving new stem cell lines from fertilized mouse eggs in fully defined, protein-free culture medium, GEM (Gamete Embryo Medium). GEM is a specialized fluid that simulates fluids in the womb. The goal of these experiments is to improve the efficiency of deriving new stem cell lines from testis biopsies. By studying time lapse videos of developing mouse embryos, Foundation scientists will pinpoint the exact time to add stem cell growth factors to the culture medium. Learn more


  • Stem Cell Research Article
  • newsletter stem cell 2010Dec 21, 2011
    The Winter 2010 Bedford Stem Cell Research Foundation newsletter (pdf)

    Workshop in Taiwan: Foundation scientists get a rare look inside Taiwan’s premiere stem cell institute. (read the blog posts)
    New steps toward a stem cell cure for HIV: Retooling cancer therapy to use HIVresistant bone marrow. (read the blog post)
    New Work on Prostate Cancer: Finding the genes for prostate cancer.


  • Stem Cell Research Article
  • stem cell researchDec 14, 2011
    Evidence for the cure of HIV infection by CCR5 - 32 stem cell transplantation

    Timothy Ray Brown can personally affirm that stem cells cure HIV disease, according to a December 2 report in the journal BLOOD. Mr. Brown, an HIV-positive American living in Germany, had leukemia and underwent chemotherapy and bone marrow transplantation in Berlin in 2007. His bone marrow match carried a rare gene mutation in the CCR5 receptor protein, rendering the transplanted cells resistant to HIV infection. Twenty months following the bone marrow transplant, the German team reported Mr. Brown's leukemia appeared cured, and there was no evidence of HIV in his blood even though he had stopped his antiviral medication prior to the bone marrow transplant. Read more

  • Stem Cell Research Article
  • stem cell researchJan 18, 2011
    Q & A with the Director

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LEARN ABOUT STEM CELL RESEARCH
Stem Cell Research Article

What is an Induced Pluripotent Stem Cell?
Discovered by Shinya Yamanaka, MD, PhD at Japan's Kyoto University in 2007, these new stem cells give rise to a totally new category of pluripotent stem cell.

WATCH THE 1 MINUTE VIDEO

MORE VIDEOS: Learn about the four kinds of pluripotent stem cells. Find out the crucial difference between Embryonic Stem Cells, Nuclear Transplant Stem Cells, Parthenogenic Stem Cells and Induced Pluripotent Stem Cells. Plus, what's the difference between an Ovasome and an Embryo?

LEARN ABOUT EGG DONATION
Stem Cell Research Article

The Human Egg Donor Program
BSCRF has the first and only human egg donor program of its kind in the nation. Learn more about BSCRF's stringent ethics advisory board and the protocol that has set the standard for today's emerging human egg donor programs.

Stem Cell Research News

Videos of Symposium Keynote Speakers:

Ian WilmutIan Wilmut2007: Ian Wilmut, DVM, PhD, "Cloning in the 10 Years Since Dolly"

Alan Trounson2006: Alan Trounson, MSc, PhD, Keynote Speaker "Pluripotent Stem Cells: the Future?"

Anne McLaren2005: Anne McLaren, PhD, Keynote Speaker "Human Eggs: Why do we need them? How do we get them?"

George Daley2004: George Daley, MD, PhD, Keynote Speaker "Stem Cells in Regenerative Medicine and Reproductive Biology"

Stem Cell Research Article

Videos from the
Spinal Cord Workshop:

spinal cord injury conference 2009: Keith Tansey, MD, PhD Neural Plasticity and Repair in SCI: Are We Doing What We Think We Are?

spinal cord injury conference 2009: The Panel Discussion Featuring: Jose Cibelli, Hans Keirstead, Douglas Kerr, John McDonald, Steven L. Stice, Keith Tansey, Scott Whittemore, Wise Young

spinal cord injury conference 2008: Wise Young, MD, PhD Spinal Cord Injury: Is the Cure in China?

spinal cord injury conference 2008: Naomi Kleitman, PhD"Translating SCI Research (Cellular Therapies): What are the Challenges?"

spinal cord injury conference 2008: Steven L. Stice, PhD "Does amplification of neural progenitor cells derived from embryonic stem cells solve problems of cell production and FDA safety standards?"

spinal cord injury conference 2008: Hans Keirstead, PhD "Challenges to the Clinical Viability of Stem Cell Technologies"

spinal cord injury conference 2008: Jose Cibelli, DVM, PhD "Is a need for autologous stem cells a barrier to spinal cord injury treatment?"

spinal cord injury conference 2008: The Panel Discussion Featuring all the 2008 faculty in a 2-Part Panel Discussion of the issues presented during the workshop.


stem cell blog  SCIENCE HIGHLIGHTS
 A series by Ann Kiessling, PhD
Stem Cell Research Article

HIV TherapyAugust 2010: Preliminary Injunction against Federal Funds for Stem Cell Research: What does it mean?


HIV TherapyJune 2010: Curing HIV Disease With Stem Cell Therapy

 


state of the unionMarch 2010: Patient-Specific, Pluripotent Stem Cells - Testis is a New Source

 


state of the unionJanuary 2010:
The State of the Stem Cell

Too many choices?
What type of pluripotent stem cell will ultimately... (more)


hiv stem cellCan stem cells cure HIV?
Winter 2009/2010 Newsletter: A promising new case report of stem cell therapy for leukemia re-opens the possibility of curing HIV infection with stem cell transplantation (read more)

stem cell blog RECENT STORIES
 Popular Foundation news
Stem Cell Research Article

ivar mendezActivated Egg Symposium
November 5, 2010: The 8th Annual Symposium kicked off with keynote, Dr. Ivar Mendez, Head of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada. Dr. Mendez gave a talk titled, "Stem Cell Transplantation for Parkinson's Disease and Spinal Cord Injury," and covered the new methods he is developing for delivering stem cells to the brain and the spinal cord.(read more)

Stem Cell Research Article

john's voiceJohn Merkins Jr. Memorial Fund
October 16th, 2010: Memorial Service. The Foundation is proud to serve the memory of this remarkable quadraplegic double cancer survivor. (more)

Stem Cell Research Article

conference of regenerative medicineJune 22, 2010
2010 ISSCR: a remarkable lack of new clinical trials for stem cell therapy announced


conference of regenerative medicineApril 23, 2010, Day Two:
Reports from the Front Lines of Stem Cell Therapy Around the World



conference of regenerative medicineApril 22, 2010, Day One:
The International Conference of Stem Cells and Regenerative Medicine for Neurodegenerative Diseases


Early Human Emrbyos - JournalEarly Human Embryos Make "Mistakes" as a Matter of Survival, Could Be Key to Understanding Stem Cell Development

April 7, 2010: Published in the Journal of Assisted Reproduction and Genetics (read more)


Ann Kiessling Gabbay AwardGabbay Award honors Dr. Ann Kiessling
Nov 16, 2009:
101 healthy babies have been born from SPAR, the Special Program of Assisted Reproduction (read more)