“The Foundation is a forward thinking institution that covers overhead costs by fee-for-service testing, thus allowing philanthropic donations to go directly to research.” - Alan Geismer, Chairman,
Board of Trustees
The average foundation laboratory experiment costs $90,000. Because most of our overhead is covered by fee-for-service laboratory tests, every dollar you donate goes directly toward these experiments. This innovative funding model allows Bedford Research scientists greater flexibility to move the work quickly in promising new directions. Progress requires meeting our annual funding goals. Please become a supporter and help us do more experiments this year.
Stem cells have a circadian rhythm that may be crucial for optimum development in the laboratory.
Until this fall, scientists have been unable to discover the circadian signal needs of stem cells from the PerLuc mouse because of the lack of a microscope sensitive enough to detect and photograph the glow of a small number of cells.
Olympus released a brand new microscope (the LV200) this year in the US and loaned Bedford Research scientists a demonstration this fall during which we discovered that our PerLuc stem cells do, indeed “glow” (see the images).
Dr. Ann Kiessling to give 2014 OSU commencement address in Reser Stadium
Foundation director, Dr. Ann Kiessling, will receive an honorary doctorate and give the 2014 commencement at Oregon State University this June. Dr. Kiessling earned a doctorate in biochemistry and biophysics from OSU. See full post.
Update June 15, 2014:Commencement Address a Success
Despite a prank from University of Oregon, Dr. Kiessling's message about taking an active role in government hit home with the largest graduating class in OSU history. read more...
Update June 18, 2014:Pilot of the "Go Ducks" Plane to Donate $500 to Bedford Research "We knew that the “Go Ducks !” message would be controversial, but we never imagined the depth of the offense our error in judgment has caused."
Cytomegalovirus (CMV) is more common in semen than generally thought, according to a new study by Bedford Research Foundation scientists.
CMV is a common herpes virus that causes a minor disease in children and adults, but can also infect fetuses in utero and causes permanent problems in 1 out of 750 children born in the U.S.
In the February issue of Fertility and Sterility, the official journal of the American Society for Reproductive Medicine (ASRM), Bedford Research scientists report two surprising findings: First, nearly half (45%) of the semen specimens from 68 men without and with HIV co-infection had detectable CMV, including specimens from two men who initially tested negative for antibody against CMV in their blood. Second, men with even mild suppression of their immune system were twice as likely (57%) to have CMV in their semen as men with normal immunity (28%).
Check out the Symposium website to learn more about this year's speakers. Treena Livingston Arinzeh, PhD - NJIT,
David Battaglia, PhD, H.C.L.D. - OHSU,
Gordon G. Carmichael, PhD - UConn Health Center,
Jose Cibelli, DVM, PhD - Michigan State University,
David DiGiusto, PhD - City of Hope,
Ken Livak, PhD - Broad Institute,
Kimberly D. Tremblay, PhD - UMass Amherst,
with dinner speaker Rudolf Jaenisch, PhD - MIT. Read More
Join us in person or watch it live online! Dr. Mario Capecchi will keynote the tenth annual Symposium. Dr. Capecchi is a Distinguished Professor of Human Genetics & Biology at the University of Utah School of Medicine, an Investigator with the Howard Hughes Medical Institute, as well as a 2007 Nobel Laureate for Physiology & Medicine.
Stem cell-based treatments, termed regenerative medicine, are being developed to replace defective tissues and organs such as heart and kidney failure, spinal cord injury and disease, diabetes, AIDS, Parkinson’s and Alzheimer’s diseases, and degenerative joints. The source of the stem cells is key. If they can be harvested from the patient, there will be no problems with tissue rejection, such as can happen with kidney or heart or bone marrow transplants from donors. SCNT provides a powerful method to create stem cells with the patient’s own chromosomes, thus a perfect tissue match. SCNT had been accomplished in many species, but not human.
In the course of trying to understand how cells became committed to each tissue and organ in the body, scientists discovered that if the chromosomes were removed from an egg, and replaced with the chromosomes (in the nucleus) of an adult cell, it was possible to stimulate the egg to begin to divide into multiple cells just as if it had been fertilized with sperm. Thus, nuclear transplantation refers to the process of replacing egg chromosomes with the chromosomes of another cell, usually a cell that has been growing in the laboratory. This research success made it possible to try to clone adult animals. It is important to note that the success rate in cloning animals is very low, fewer than 1% of eggs that undergo nuclear transplantation, but the success rate in stimulating the transplanted egg into dividing into multiple cells is high. Thus, such transplanted eggs may be ideal candidates for stem cells, but not for producing clones. Read more in our FAQ
Update on Spinal Cord Workshop: Hans Keirstead, PhD Gives Tedx Talk: "Innocent Intrigue"
The Spinal Cord Workshop
Join us on Friday, November 9: What Are The Barriers to Cure? Since 2008 this powerful workshop has been bringing together scientists and clinical practitioners to hash out the current state of stem cell research and spinal cord injury treatments.
Dr. Kiessling will give a talk titled, "Totipotency, Pluripotency and Growth Factors". She'll be joined by Plenary Speaker: Dr. Sandra Engle of Pfizer, and Featured Speakers: Dr. Mark Tomishima, Sloan-Kettering, Dr. Danwei Huangfu, Sloan-Kettering, Dr. Noemi Fusaki of DNAVEC Corp., and Dr. Nirupama Shevde of Life Technologies, Inc.
What Are The Barriers to Cure? Since 2008 this powerful workshop has been bringing together scientists and clinical practitioners to hash out the current state of stem cell research and spinal cord injury treatments.
This year's faculty speakers include: Jose Cibelli, DVM, PhD, Philip Horner, PhD, Hans Keirstead, PhD, Ann A. Kiessling, PhD,
Steven L. Stice, PhD,
Keith Tansey, MD, PhD, and Wise Young, PhD.
More information and speakers will be announced shortly.
The current raucous debate over the commonly used PSA blood test to screen for prostate cancer, the third leading cause of cancer deaths in men in the U.S.(a), stems from the U.S. Preventive Services Task Force’s recommendation to discontinue PSA screening(b). The debate is pitting physician against physician, cancer advocacy groups against health care insurance companies, and leaving men with enormous questions about what to do about their lifetime risk of developing prostate cancer.
The Task Force’s recommendation is based on it’s review of medical literature that concluded that PSA screening leads to more unnecessary treatment complications than are justified by lives saved because... Read More
A recent article in Scientific American questioned whether research on stem cell lines derived from unfertilized eggs was too tightly regulated by the federal government. Now that technology allows the creation of stem cells without fertilization, there is no question that federal laws and guidelines are overly restrictive, causing a detrimental effect on valuable scientific inquiry.
Since 1996, Congress has included the Dickey-Wicker Amendment in the annual federal budget. This amendment was a conservative reaction to what some considered to be scientific research that showed little respect toward life.... Read More
My support for stem cell research has its foundation in my deep-seeded belief in reproductive rights for women. Since I came of age in the 1970’s, women’s reproductive rights and freedom have been continually eroded by federal and state legislation. That has been coupled with diminished government support and funding – ranging from access to abortion services to stem cell research. Because of that, I have volunteered time and donated money to help preserve these rights.
But last summer, my support for stem cell research became personal. During a mugging on the Cape, my stepson was shot by the assailant, resulting in a severed spinal cord at T-5. He’s now a parapalegic... Read More
BSCRF scientists have derived two unique lines of stem cells that may lead to a breakthrough in the efficiency of stem cell derivation and expansion.
BSCRF scientists are following up their discovery that the genes that regulate the rhythms of daily life, circadian rhythm genes, may play important roles in stem cell derivation and stability in culture. Circadian rhythm genes regulate cells in the body by turning “on” and “off” over a 24-hour cycle in response to signals such as light/dark cycles, hormone pulses, and body temperature variations. Read More
In This Issue:Progress in Circadian Rhythms and Stem Cells, Developing the First Circadian Incubator, Doing More With Less: A Letter From the Director, Testis Project Update, The 2011 Activated Egg Symposium, Victoria Staeble Joins the Board of Trustees and more.
Download the PDF or join the mailing list to get a hard copy delivered right to your door!
MORE VIDEOS: Learn about the four kinds of pluripotent stem cells. Find out the crucial difference
between Embryonic Stem Cells, Nuclear Transplant Stem
Cells, Parthenogenic Stem Cells and Induced Pluripotent Stem Cells. Plus, what's
the difference between an Ovasome and an Embryo?
LEARN ABOUT EGG DONATION
The Human Egg Donor Program
BSCRF has the first and only human egg donor program of its kind in the nation. Learn more about BSCRF's stringent ethics advisory board and the protocol that has set the standard for today's emerging human egg donor programs.