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  • Learn About Our Work

    Thank you to the generous support of Sasha Goldberg for producing and animating this video.

  • Stem Cell Research Article
  • December 2, 2014

    Bedford Research 2014 Annual Appeal

    “The Foundation is a forward thinking institution that covers overhead costs by fee-for-service testing, thus allowing philanthropic donations to go directly to research.”
                             - Alan Geismer, Chairman, Board of Trustees

    Each Experiment Brings Us Closer

    The average foundation laboratory experiment costs $90,000. Because most of our overhead is covered by fee-for-service laboratory tests, every dollar you donate goes directly toward these experiments. This innovative funding model allows Bedford Research scientists greater flexibility to move the work quickly in promising new directions. Progress requires meeting our annual funding goals. Please become a supporter and help us do more experiments this year.

    donate to stem cell research

    Donate Now  Read More

  • Stem Cell Research Article
  • November 20, 2014

    SCIENCE UPDATE - FALL / WINTER 2014

    Bedford Research Stem Cells Glow!

    circadian rhythm in stem cellsStem cells have a circadian rhythm that may be crucial for optimum development in the laboratory.
    Until this fall, scientists have been unable to discover the circadian signal needs of stem cells from the PerLuc mouse because of the lack of a microscope sensitive enough to detect and photograph the glow of a small number of cells.

    Olympus released a brand new microscope (the LV200) this year in the US and loaned Bedford Research scientists a demonstration this fall during which we discovered that our PerLuc stem cells do, indeed “glow” (see the images).

    Read the full article| Download the PDF

  • Stem Cell Research Article
  • June 12, 2014

    Dr. Ann Kiessling to give 2014 OSU commencement address in Reser Stadium

    Foundation director, Dr. Ann Kiessling, will receive an honorary doctorate and give the 2014 commencement at Oregon State University this June. Dr. Kiessling earned a doctorate in biochemistry and biophysics from OSU. See full post.

    Previous speakers include: Michelle Obama (youtube), Major General Julie A. Bentz, PhD., and Jon DeVaan (Microsoft). OSU Commencement Info.

    Update June 15, 2014: Commencement Address a Success
    Despite a prank from University of Oregon, Dr. Kiessling's message about taking an active role in government hit home with the largest graduating class in OSU history. read more...

    Update June 18, 2014: Pilot of the "Go Ducks" Plane to Donate $500 to Bedford Research
    "We knew that the “Go Ducks !” message would be controversial, but we never imagined the depth of the offense our error in judgment has caused." read more...

  • Stem Cell Research Article
  • March 24, 2014

    Cytomegalovirus (CMV) is More Common in Semen Than Generally Thought, According to a New Study by Bedford Scientists

    Cytomegalovirus (CMV) is more common in semen than generally thought, according to a new study by Bedford Research Foundation scientists.

    CMV is a common herpes virus that causes a minor disease in children and adults, but can also infect fetuses in utero and causes permanent problems in 1 out of 750 children born in the U.S.

    In the February issue of Fertility and Sterility, the official journal of the American Society for Reproductive Medicine (ASRM), Bedford Research scientists report two surprising findings: First, nearly half (45%) of the semen specimens from 68 men without and with HIV co-infection had detectable CMV, including specimens from two men who initially tested negative for antibody against CMV in their blood. Second, men with even mild suppression of their immune system were twice as likely (57%) to have CMV in their semen as men with normal immunity (28%).

    Read More

  • Stem Cell Research Article
  • November 12, 2013

    activated egg symposium videosWatch the AES 2013 Talks

    The amazing talks presented at the Activated Egg Symposium last Friday are available for viewing at Ustream.tv for a limited time.

  • Stem Cell Research Article
  • November 6, 2013

    The Activated Egg Symposium - Nov 8

    Check out the Symposium website to learn more about this year's speakers. Treena Livingston Arinzeh, PhD - NJIT, David Battaglia, PhD, H.C.L.D. - OHSU, Gordon G. Carmichael, PhD - UConn Health Center, Jose Cibelli, DVM, PhD - Michigan State University, David DiGiusto, PhD - City of Hope, Ken Livak, PhD - Broad Institute, Kimberly D. Tremblay, PhD - UMass Amherst, with dinner speaker Rudolf Jaenisch, PhD - MIT. Read More

    9:00 AM Ken Livak, PhD

    “Driving Genomics to the Single-Cell Level"

    9:30 AM Keynote:
    Dr. Mario Capecchi

    "Gene Targeting into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders."

    10:50 AM David Battaglia, Ph.D., H.C.L.D.

    "Human Egg Donation for Somatic Cell Nuclear Transfer: The Oregon Perspective"

    11:40 AM Jose Cibelli, DVM, PhD

    "Modeling Reprogramming Using Zebrafish Somatic Cell Nuclear Transfer."

    1:30 PM David DiGiusto, PhD

    "Ex Vivo Engineering of Human Hematopoietic Stem Cells: Gene Therapy Towards a Cure for AIDS."

     
     

    2:20 PM Gordon G. Carmichael, Ph.D.

    "Innate immunity in stem cells."

    3:30 PM Kimberly D. Tremblay, Ph.D.

    “Understanding liver development; embryonic origins and bud formation.”

    4:20 PM Treena Livingston Arinzeh, PhD

    "Biomaterials for Stem Cell Tissue Engineering."

    6:00 PM Dinner Speaker: Rudolf Jaenisch, PhD

    "Stem cells and reprogramming: What's the big deal?"

    Learn more about watching online and register here.

  • Stem Cell Research Article
  • Sept 12, 2013

    The Activated Egg Symposium - Registration Open!

    activated egg symposium

    Register Today for the November 8, 2013 One-Day Symposium!

    Join us in person or watch it live online! Dr. Mario Capecchi will keynote the tenth annual Symposium. Dr. Capecchi is a Distinguished Professor of Human Genetics & Biology at the University of Utah School of Medicine, an Investigator with the Howard Hughes Medical Institute, as well as a 2007 Nobel Laureate for Physiology & Medicine.

  • Stem Cell Research Article
  • June 5, 2013

    SCIENCE HIGHLIGHTS - JUNE 2013

    Human Somatic Cell Nuclear Transfer For Patient Specific Stem Cells: Will It Work?

    What is somatic cell nuclear transfer (SCNT)?

    human egg blue dna SCNT is a phrase coined by scientists to describe the process of injecting the nucleus (which contains the chromosomes) from another cell in the body into a human egg. Last week a team of Oregon scientists reported creating four unique stem cells by this process (Cell, June, 2013 (pdf)). This work is a follow-up to studies originally reported by Bedford Research Foundation scientists, Jose Cibelli and Ann Kiessling, in 2001 (Somatic Cell Nuclear Transfer in Humans: Pronuclear and Early Embryonic Development. J of Regenerative Medicine (pdf)).

    Why are the new stem cells important?

    Stem cell-based treatments, termed regenerative medicine, are being developed to replace defective tissues and organs such as heart and kidney failure, spinal cord injury and disease, diabetes, AIDS, Parkinson’s and Alzheimer’s diseases, and degenerative joints. The source of the stem cells is key. If they can be harvested from the patient, there will be no problems with tissue rejection, such as can happen with kidney or heart or bone marrow transplants from donors. SCNT provides a powerful method to create stem cells with the patient’s own chromosomes, thus a perfect tissue match. SCNT had been accomplished in many species, but not human.

    (read the full article)

  • Stem Cell Research Article
  • May 29, 2013

    What is Somatic Cell Nuclear Transfer?

    In the course of trying to understand how cells became committed to each tissue and organ in the body, scientists discovered that if the chromosomes were removed from an egg, and replaced with the chromosomes (in the nucleus) of an adult cell, it was possible to stimulate the egg to begin to divide into multiple cells just as if it had been fertilized with sperm. Thus, nuclear transplantation refers to the process of replacing egg chromosomes with the chromosomes of another cell, usually a cell that has been growing in the laboratory. This research success made it possible to try to clone adult animals. It is important to note that the success rate in cloning animals is very low, fewer than 1% of eggs that undergo nuclear transplantation, but the success rate in stimulating the transplanted egg into dividing into multiple cells is high. Thus, such transplanted eggs may be ideal candidates for stem cells, but not for producing clones. Read more in our FAQ



  • Stem Cell Research Article
  • June 12-15, 2013

    Visit Our Booth at the ISSCR in Boston

    The Foundation is presenting a poster and will be in booth #823. Please stop by!



  • Stem Cell Research Article
  • February 1, 2013

    Spinal Cord Workshop Videos Available!

    Watch the talks from the eye-opening workshop this past November.

    Other speakers include: Philip Horner, PhD, Ann A. Kiessling, PhD, Keith Tansey, MD, PhD, and Wise Young, PhD.

  • Stem Cell Research Article
  • November 7, 2012

    Update on Spinal Cord Workshop: Hans Keirstead, PhD Gives Tedx Talk: "Innocent Intrigue"

    The Spinal Cord Workshop
    Join us on Friday, November 9: What Are The Barriers to Cure?
    Since 2008 this powerful workshop has been bringing together scientists and clinical practitioners to hash out the current state of stem cell research and spinal cord injury treatments.

    Other speakers include: Philip Horner, PhD, Ann A. Kiessling, PhD, Keith Tansey, MD, PhD, and Wise Young, PhD.

  • Stem Cell Research Article
  • September 17, 2012

    Dr. Ann A. Kiessling to Keynote New Jersey Stem Cell Research Symposium

    The Sixth Annual New Jersey Stem Cell Research Symposium will be held from 10:00 AM to 6:00 PM on September 19, 2012 at the Bridgewater Marriott.

    Dr. Kiessling will give a talk titled, "Totipotency, Pluripotency and Growth Factors". She'll be joined by Plenary Speaker: Dr. Sandra Engle of Pfizer, and Featured Speakers: Dr. Mark Tomishima, Sloan-Kettering, Dr. Danwei Huangfu, Sloan-Kettering, Dr. Noemi Fusaki of DNAVEC Corp., and Dr. Nirupama Shevde of Life Technologies, Inc.

    Register to attend

  • Stem Cell Research Article
  • The 2012 Spinal Cord WorkshopSeptember 6, 2012

    Join Us on November 9, 2012 in Weston, MA - Come in Person or Watch Online!

    What Are The Barriers to Cure? Since 2008 this powerful workshop has been bringing together scientists and clinical practitioners to hash out the current state of stem cell research and spinal cord injury treatments.

    This year's faculty speakers include: Jose Cibelli, DVM, PhD, Philip Horner, PhD, Hans Keirstead, PhD, Ann A. Kiessling, PhD, Steven L. Stice, PhD, Keith Tansey, MD, PhD, and Wise Young, PhD. More information and speakers will be announced shortly.

    Register to attend in person or watch online!

  • Stem Cell Research Article
  • June 5, 2012

    PSA Test, PSA ScreeningTo PSA or Not to PSA: That is the Question
    Science Highlights, by Ann A. Kiessling, PhD

    The current raucous debate over the commonly used PSA blood test to screen for prostate cancer, the third leading cause of cancer deaths in men in the U.S.(a), stems from the U.S. Preventive Services Task Force’s recommendation to discontinue PSA screening(b). The debate is pitting physician against physician, cancer advocacy groups against health care insurance companies, and leaving men with enormous questions about what to do about their lifetime risk of developing prostate cancer.

    The Task Force’s recommendation is based on it’s review of medical literature that concluded that PSA screening leads to more unnecessary treatment complications than are justified by lives saved because... Read More

  • Stem Cell Research Article
  • December 15, 2011

    Sean KealyOver-Regulation of Parthenotes Stifles Valuable Scientific Research
    by Sean Kealy, posted in the UPenn Law RegBlog

    A recent article in Scientific American questioned whether research on stem cell lines derived from unfertilized eggs was too tightly regulated by the federal government. Now that technology allows the creation of stem cells without fertilization, there is no question that federal laws and guidelines are overly restrictive, causing a detrimental effect on valuable scientific inquiry.

    Since 1996, Congress has included the Dickey-Wicker Amendment in the annual federal budget. This amendment was a conservative reaction to what some considered to be scientific research that showed little respect toward life.... Read More

  • Stem Cell Research Article
  • December 7, 2011

    Victoria StaeblerWhy I Support Stem Cell Research by Victoria Staebler

    My support for stem cell research has its foundation in my deep-seeded belief in reproductive rights for women. Since I came of age in the 1970’s, women’s reproductive rights and freedom have been continually eroded by federal and state legislation. That has been coupled with diminished government support and funding – ranging from access to abortion services to stem cell research. Because of that, I have volunteered time and donated money to help preserve these rights.

    But last summer, my support for stem cell research became personal. During a mugging on the Cape, my stepson was shot by the assailant, resulting in a severed spinal cord at T-5. He’s now a parapalegic... Read More

  • Stem Cell Research Article
  • November 17, 2011

    IN THE LAB

    Current Stem Cell ResearchProgress in Circadian Rhythms and Stem Cells

    BSCRF scientists have derived two unique lines of stem cells that may lead to a breakthrough in the efficiency of stem cell derivation and expansion.

    BSCRF scientists are following up their discovery that the genes that regulate the rhythms of daily life, circadian rhythm genes, may play important roles in stem cell derivation and stability in culture. Circadian rhythm genes regulate cells in the body by turning “on” and “off” over a 24-hour cycle in response to signals such as light/dark cycles, hormone pulses, and body temperature variations. Read More

  • Stem Cell Research Article
  • Current Stem Cell ResearchNovember 10, 2011

    The BSCRF Newsletter - Winter 2011

    In This Issue: Progress in Circadian Rhythms and Stem Cells, Developing the First Circadian Incubator, Doing More With Less: A Letter From the Director, Testis Project Update, The 2011 Activated Egg Symposium, Victoria Staeble Joins the Board of Trustees and more.

    Download the PDF or join the mailing list to get a hard copy delivered right to your door!

  • Stem Cell Research Article
  • embryos and parthenotes Scientific AmericaNovember 4, 2011
    "You Say Embryo, I Say Parthenote", BSCRF and the importance of parthenote stem cells reported in the November, 2011 Scientific American by Julia Galef.
  • Stem Cell Research Article

     
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LEARN ABOUT STEM CELL RESEARCH

What is an Induced Pluripotent Stem Cell?
Discovered by Shinya Yamanaka, MD, PhD at Japan's Kyoto University in 2007, these new stem cells give rise to a totally new category of pluripotent stem cell.

WATCH THE 1 MINUTE VIDEO

MORE VIDEOS: Learn about the four kinds of pluripotent stem cells. Find out the crucial difference between Embryonic Stem Cells, Nuclear Transplant Stem Cells, Parthenogenic Stem Cells and Induced Pluripotent Stem Cells. Plus, what's the difference between an Ovasome and an Embryo?

LEARN ABOUT EGG DONATION

The Human Egg Donor Program
BSCRF has the first and only human egg donor program of its kind in the nation. Learn more about BSCRF's stringent ethics advisory board and the protocol that has set the standard for today's emerging human egg donor programs.


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