Masahito Tachibana, Paula Amato, Michelle Sparman, Nuria Marti Gutierrez, Rebecca Tippner-Hedges, Ho
Reprogramming somatic cells into pluripotent em- bryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)- ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to pro- duce human NT-ESCs have failed secondary to early embryonic arrest of SCNT…