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Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints

June, 2010: The second report by Bedford scientists about cell division appeared, as the cover story of the JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. The work builds on the previous report of CLOCK genes that indicate early stem cells may be under the control of circadian rhythms (see report at bedfordresearch.org). These novel findings about…

Somatic Cell Nuclear Transfer in Humans: Pronuclear and Early Embryonic Development

Human therapeutic cloning requires the reprogramming of a somatic cell by nuclear transfer to generate autologous totipotent stem cells. We have parthenogenetically activated 22 human eggs and also performed nuclear transfer in 17 metaphase II eggs. Cleavage beyond the eight-cell stage was obtained in the parthenogenetic-activate d eggs, and blastocoele cavities were observed in six….

Poly (A)-Oligo (dT) – Stimulated DNA Polymerase Activity in Preimplantation Mouse Embryos

[Article Removed] This report, published 28 years ago by JEZ, a Wiley-Liss journal, has been replaced with this letter from a representative of Wiley-Liss claiming Bedford Research Foundation owes Wiley-Liss royalties for this article. Under current U. S. government guidelines, put in place in 2008, this article would be available to the general public free…