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June, 2013 | Cell 153, 1–11, http://dx.doi.org/10.1016/j.cell.2013.05.006.
Masahito Tachibana, Paula Amato, Michelle Sparman, Nuria Marti Gutierrez, Rebecca Tippner-Hedges, Ho  

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

Reprogramming somatic cells into pluripotent em- bryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)- ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to pro- duce human NT-ESCs have failed secondary to early embryonic arrest of SCNT…

June, 2010 | Journal of Assisted Reproduction Genetics, Vol 27, No 6
Kiessling A, Bletsa R, Desmarais B, Mara C, Kallianidis K, Loutradis D  

Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints

June, 2010: The second report by Bedford scientists about cell division appeared, as the cover story of the JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. The work builds on the previous report of CLOCK genes that indicate early stem cells may be under the control of circadian rhythms (see report at bedfordresearch.org). These novel findings about…

March, 2010 | Phil. Trans. R. Soc. B 2010 365, 155-163, doi: 10.1098/rstb.2009.0149.
Watt, Fiona M. and Driskell, Ryan R.  

The therapeutic potential of stem cells

In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem cells that have been described: their origins in embryonic and adult tissues and their differentiation potential in vivo…

February, 2009 | J. Assist. Reprod. Genet., (2009) 26:187 – 195 DOI 10.1007/s10815-009-9306-x.
Ann A. Kiessling, Ritsa Bletsa, Bryan Desmarais, Christina Mara, Kostas Kallianidis, Dimitris Loutra  

Evidence that human blastomere cleavage is under unique cell cycle control

PURPOSE: To understand the molecular pathways that control early human embryo development. METHODS: Improved methods of linear amplification of mRNAs and whole human genome microarray analyses were utilized to characterize gene expression in normal appearing 8-Cell human embryos, in comparison with published micro-arrays of human fibroblasts and pluripotent stem cells. RESULTS: Many genes involved in…