Search in library posts

February, 2024 | Journal of Assisted Reprodroduction and Genetics . 2024 Feb;41(2):323-332. doi: 10.1007/s10815-023-03002-8. Epub 2023 Dec 22.
Harris A, Dinopoulou V, Loutradis D, Drakakis P, Kiessling A  

Microarray evidence that 8‑cell human embryos express some hormone family members including oxytocin

Abstract Objective This study is to discover hormone pathways active in early cleaving human embryos. Methods A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency. Results Over half of the…

October, 2015 | Stem Cells and Development. 2015 Oct 22;25(2):160–177.
Vlismas A, Bletsa R, Mavrogianni D, Mamali G, Pergamali M, Dinopoulou V, Partsinevelos G, Drakakis P, Loutradis D, Kiessling A.  

Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells

Previous microarray analyses of RNAs from 8-cell (8C) human embryos revealed a lack of cell cycle check-points and overexpression of core circadian oscillators and cell cycle drivers relative to pluripotent human stem cells [human embryonic stem cells/induced pluripotent stem (hES/iPS)] and fibroblasts, suggesting growth factor independence during early cleavage stages. To explore this possibility, we queried…