Bedford Research Foundation Open House Next Week!

The Bedford Research Foundation (BRF) is hosting two open houses Thursday, April 30 from 5:30 – 8:00 pm, and Saturday, May 2 from 4:00 – 6:00 pm for local residents and members of the biomedical, healthcare, and manufacturing industries. The event is open to the public and includes a short presentation by foundation director, Dr. Ann Kiessling, as well as demonstrations and tours of the foundation’s new space at 124 South Road, Bedford, MA. Meet staff and board members and find out more about the many exciting projects currently underway.  Representative Ken Gordon and senator Mike Barrett will be on hand for the ribbon cutting ceremony.

Bedford Research Foundation is a not-for-profit biomedical institute conducting stem cell and related research to help find cures for diseases presently considered incurable. In the words of board member Victoria Staebler,:

“The stem cell research that BRF is doing is laying the foundation for regenerative cell therapy that could potentially cure not only spinal cord injury victims like him [sic], but an incredible range of diseases, from Parkinson’s to bone marrow cancer.”

Bedford Research Foundation is proud of its many innovative projects in stem cell growth and culture, programs targeted at diseases like prostatitis and prostate cancer, and services for couples living with infectious disease.

Visitors are encouraged to meet foundation representatives, tour the new BRF research and laboratory facility, and learn more about stem cell research – what it is, how far it’s come, and where it needs to go from here.

About Bedford Research Foundation

BRF has been doing cost-effective research to high standards for almost 20 years, demonstrating that individuals can make a huge difference in areas traditionally dominated by universities or government agencies. More information is available on the web at


Ground breaking work with fellowship money

Bedford Research Foundation supports ground breaking work with fellowship money

As the result of a generous benefactor, the Bedford Research Foundation has placed a fellow in Spain who is contributing significantly to understanding cellular programming and pluripotency in Stem Cells.

Dr. Sebastian Canovas is a Principal Investigator researcher from the Program for Cell Therapy and Regenerative Medicine of Andalucia, Foundation “Progreso y Salud”, in Seville, Spain. Dr Canovas received his DVM in 2002 from the University of Murcia (Spain) and in 2005 he completed his Master’s degree in Biotechnology of Reproduction in Mammals. During six years (2002-2008) he was working in the group Physiology of Reproduction in embryology, sperm functionality and sperm-oocyte interactions.

Following completion of his PhD, he joined Dr. Cibelli’s laboratory (Cellular Reprogramming Laboratory) at Michigan State University (USA) where his research had been focused on understanding the mechanisms of cellular reprogramming during embryo development and induced pluripotent stem cells production. To elucidate these mechanisms, Sebastian studied the role of a H3K27me3 histome demethylase (JMJD3) in bovine at early embryo development and during human make induced pluripotent stem cells process. Also, he has development a project for enhancing the efficiency in the production of safe iPS cells using episomal plasmids and adult somatic cells.

Now, his team is involved on a project to make transdifferentiation from human somatic cells forwards germinal cells. As a result of his work, he has published more than 12 scientific papers in journals with impact factor and he is collaborating in 6 research grants. Dr. Canovas hopes these studies will help lead to cures of rare disorders and fertility, which are affecting the population but they have not an effective treatment.

For more information on this fellowship and the work at this laboratory:

2014 Annual Appeal for Support

Dear Supporter,

In 1996, the Bedford Research Foundation was formed in response to a need for specialized tests and services that were not available anywhere in the world. Today, we still provide these specialized tests and it has led us to a new model of funding:

“The Foundation is a forward thinking institution that covers overhead costs with fee-for-service testing, thus allowing philanthropic donations to go directly to research.”

– Alan Geismer, Chairman, Board of Trustees
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Fall & Winter 2014 Stem Cell Research Update

Bedford Research Stem Cells Glow!

Breakthroughs in understanding circadian rhythms in stem cells.

Fall 2014: Bedford Research scientists are following up on their discovery that stem cells have a circadian rhythm that may need to be supported for optimum development in the laboratory.

In the body, the daily pattern of light and dark controls many signals sent out by the brain, such as those that trigger changes in body temperature, and feelings of hunger and sleepiness.

Stem cells may especially need circadian signals to differentiate into specific cell types, such as neurons or bone marrow — but what type of signal should they receive in the laboratory? And what frequency? There is growing evidence that each type of cell needs a different circadian signal.

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Stem Cell Research – Science Update

Following up Bedford’s discovery that stem cells may be controlled by circadian rhythms.

Bedford Research scientists discovered that stem cells may need circadian rhythm signals. This insight would make them analogous to several types of cells in the body, including some cancer cells. If true, new methods of cell culture need to be developed to enhance stem cell development. Bedford Research scientists isolated a new line of stem cells from a research mouse (Per2Luc) whose cells glow when one of the circadian genes is active (Figure 1). Efforts to study the new Per2Luc stem cells have been hindered by the lack of a sensitive photo-microscope to detect and record the glow — until very recently.  An exciting, new photo-microscope (LV200) is sensitive enough to capture circadian oscillations in the Per2Luc cells (Figure 1). This advance will allow more rapid studies of the importance of circadian signals to stem cell expansion and differentiation.

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Dr. Kiessling gives 2014 commencement to 25,000 at Oregon State University

Update June 15, 2014: Commencement Address a Success
Despite a prank from University of Oregon, Dr. Kiessling’s message about taking an active role in government hit home with the largest graduating class in OSU history. read more…

Update June 18, 2014: Pilot of the “Go Ducks” Plane to Donate $500 to Bedford Research
“We knew that the “Go Ducks !” message would be controversial, but we never imagined the depth of the offense our error in judgment has caused.” read more…

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Cytomegalovirus (CMV) is More Common in Semen Than Generally Thought, According to a New Study

Cytomegalovirus (CMV) is more common in semen than generally thought, according to a new study by Bedford Research Foundation scientists.

CMV is a common herpes virus that causes a minor disease in children and adults, but can also infect fetuses in utero and causes permanent problems in 1 out of 750 children born in the U.S.

In the February issue of Fertility and Sterility, the official journal of the American Society for Reproductive Medicine (ASRM), Bedford Research scientists report two surprising findings: First, nearly half (45%) of the semen specimens from 68 men without and with HIV co-infection had detectable CMV, including specimens from two men who initially tested negative for antibody against CMV in their blood. Second, men with even mild suppression of their immune system were twice as likely (57%) to have CMV in their semen as men with normal immunity (28%).

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Human Somatic Cell Nuclear Transfer For Patient Specific Stem Cells: Will It Work?

human egg blue dnaThe human egg is a huge cell, that is released from the ovary surrounded by cells that support it. The blue areas shown above are the DNA, the genetic information contained within each cell. The cluster of blue within the egg is the egg’s chromosomes, half of which will be expelled when the sperm enters, so the developing embryo will have genetic information from both the mother and the father.For parthenogenesis, the egg chromosomes alone guide development, for SCNT, the chromosomes are usually removed with a tiny pipette so the only genetic information remaining is from the transferred nucleus.
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