BRF Wraps Up Community Consulting Teams (CCT) Project

For the past several months Bedford Research Foundation has been working with Community Consulting Teams ( to complete a Strategic Assessment designed to help the foundation strengthen and improve communications surrounding both short and long term research projects. As part of this process, CCT has assisted the BRF in studying the potential future impacts of the work the foundation is doing. On June 9th, BRF and its team of 15 CCT MBA’s will join other organizations CCT has been working with this session to wrap up the BRF project and present findings.

Foundation Director Dr. Ann Kiessling and BRF staff are very grateful for the help and support of this wonderful organization. Below is an excerpt from CCT’s most recent newsletter:

Cutting-Edge Research to Cure Disease (BRF)
CCT is using the varied skills and backgrounds of its consultants to provide a situational assessment of the Bedford Research Foundation (BRF) to inform its strategic plan and future growth. The team is focused on understanding BRF’s mission, history, and current operations by speaking with stakeholders including staff, board members, and funders. In addition, the team is analyzing BRF financials, identifying analogous organizations to determine successful models for growth, and researching potential funding sources.

BRF Open Houses in the News

Dr. Lawitts demonstration

Dr. Lawitts demonstrates injection of mouse eggs.

A few weeks ago, Bedford Research Foundation hosted two open houses celebrating the foundation’s move to it’s new research facility at 124 South Road in Bedford, MA. The first event was geared toward local businesses and had over 30 attendees including companies from Bedford, surrounding communities, and local residents. The second event on Saturday, May 1st was open to the public and was attended by more than 60 residents and friends of the foundation. Senator Mike Barrett, Representative Ken Gordon, and Bedford Research Foundation Director Dr. Ann Kiessling cut the ribbon on BRF’s new research facility. Barrett and Gordon expressed excitement at seeing the foundation finally “come home” to Bedford after more than 15 years in Somerville.

Both events also provided a significant amount of visibility for the foundation, including coverage by local media outlets like The Boston Globe and The Bedford Minuteman. We at BRF are excited to share these articles with you here:

Bedford Research Foundation opens new stem cell research facility (

Bedford Research Foundation Opens Its New Research Facility to the Public (

INFORMER: Noodles, theater, research, and a seed library (The Boston Globe)

Bedford Research Foundation comes home to Bedford (

Bedford Research Foundation Open House Next Week!

The Bedford Research Foundation (BRF) is hosting two open houses Thursday, April 30 from 5:30 – 8:00 pm, and Saturday, May 2 from 4:00 – 6:00 pm for local residents and members of the biomedical, healthcare, and manufacturing industries. The event is open to the public and includes a short presentation by foundation director, Dr. Ann Kiessling, as well as demonstrations and tours of the foundation’s new space at 124 South Road, Bedford, MA. Meet staff and board members and find out more about the many exciting projects currently underway.  Representative Ken Gordon and senator Mike Barrett will be on hand for the ribbon cutting ceremony.

Bedford Research Foundation is a not-for-profit biomedical institute conducting stem cell and related research to help find cures for diseases presently considered incurable. In the words of board member Victoria Staebler,:

“The stem cell research that BRF is doing is laying the foundation for regenerative cell therapy that could potentially cure not only spinal cord injury victims like him [sic], but an incredible range of diseases, from Parkinson’s to bone marrow cancer.”

Bedford Research Foundation is proud of its many innovative projects in stem cell growth and culture, programs targeted at diseases like prostatitis and prostate cancer, and services for couples living with infectious disease.

Visitors are encouraged to meet foundation representatives, tour the new BRF research and laboratory facility, and learn more about stem cell research – what it is, how far it’s come, and where it needs to go from here.

About Bedford Research Foundation

BRF has been doing cost-effective research to high standards for almost 20 years, demonstrating that individuals can make a huge difference in areas traditionally dominated by universities or government agencies. More information is available on the web at


Ground breaking work with fellowship money

Bedford Research Foundation supports ground breaking work with fellowship money

As the result of a generous benefactor, the Bedford Research Foundation has placed a fellow in Spain who is contributing significantly to understanding cellular programming and pluripotency in Stem Cells.

Dr. Sebastian Canovas is a Principal Investigator researcher from the Program for Cell Therapy and Regenerative Medicine of Andalucia, Foundation “Progreso y Salud”, in Seville, Spain. Dr Canovas received his DVM in 2002 from the University of Murcia (Spain) and in 2005 he completed his Master’s degree in Biotechnology of Reproduction in Mammals. During six years (2002-2008) he was working in the group Physiology of Reproduction in embryology, sperm functionality and sperm-oocyte interactions.

Following completion of his PhD, he joined Dr. Cibelli’s laboratory (Cellular Reprogramming Laboratory) at Michigan State University (USA) where his research had been focused on understanding the mechanisms of cellular reprogramming during embryo development and induced pluripotent stem cells production. To elucidate these mechanisms, Sebastian studied the role of a H3K27me3 histome demethylase (JMJD3) in bovine at early embryo development and during human make induced pluripotent stem cells process. Also, he has development a project for enhancing the efficiency in the production of safe iPS cells using episomal plasmids and adult somatic cells.

Now, his team is involved on a project to make transdifferentiation from human somatic cells forwards germinal cells. As a result of his work, he has published more than 12 scientific papers in journals with impact factor and he is collaborating in 6 research grants. Dr. Canovas hopes these studies will help lead to cures of rare disorders and fertility, which are affecting the population but they have not an effective treatment.

For more information on this fellowship and the work at this laboratory:

2014 Annual Appeal for Support

Dear Supporter,

In 1996, the Bedford Research Foundation was formed in response to a need for specialized tests and services that were not available anywhere in the world. Today, we still provide these specialized tests and it has led us to a new model of funding:

“The Foundation is a forward thinking institution that covers overhead costs with fee-for-service testing, thus allowing philanthropic donations to go directly to research.”

– Alan Geismer, Chairman, Board of Trustees
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Fall & Winter 2014 Stem Cell Research Update

Bedford Research Stem Cells Glow!

Breakthroughs in understanding circadian rhythms in stem cells.

Fall 2014: Bedford Research scientists are following up on their discovery that stem cells have a circadian rhythm that may need to be supported for optimum development in the laboratory.

In the body, the daily pattern of light and dark controls many signals sent out by the brain, such as those that trigger changes in body temperature, and feelings of hunger and sleepiness.

Stem cells may especially need circadian signals to differentiate into specific cell types, such as neurons or bone marrow — but what type of signal should they receive in the laboratory? And what frequency? There is growing evidence that each type of cell needs a different circadian signal.

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Stem Cell Research – Science Update

Following up Bedford’s discovery that stem cells may be controlled by circadian rhythms.

Bedford Research scientists discovered that stem cells may need circadian rhythm signals. This insight would make them analogous to several types of cells in the body, including some cancer cells. If true, new methods of cell culture need to be developed to enhance stem cell development. Bedford Research scientists isolated a new line of stem cells from a research mouse (Per2Luc) whose cells glow when one of the circadian genes is active (Figure 1). Efforts to study the new Per2Luc stem cells have been hindered by the lack of a sensitive photo-microscope to detect and record the glow — until very recently.  An exciting, new photo-microscope (LV200) is sensitive enough to capture circadian oscillations in the Per2Luc cells (Figure 1). This advance will allow more rapid studies of the importance of circadian signals to stem cell expansion and differentiation.

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Dr. Kiessling gives 2014 commencement to 25,000 at Oregon State University

Update June 15, 2014: Commencement Address a Success
Despite a prank from University of Oregon, Dr. Kiessling’s message about taking an active role in government hit home with the largest graduating class in OSU history. read more…

Update June 18, 2014: Pilot of the “Go Ducks” Plane to Donate $500 to Bedford Research
“We knew that the “Go Ducks !” message would be controversial, but we never imagined the depth of the offense our error in judgment has caused.” read more…

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