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2010 Newsletter: The Testis: a source of stem cells for all men?

Could the newly discovered “testis stem cells” be as versatile as embryonic stem cells? Bedford is launching a major research initiative to find out. A major barrier to progress in stem cell therapies is that, similar to organ transplantation, the body rejects cells that are not a good match for the patient. Surprisingly, stem cells…

The therapeutic potential of stem cells

In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem cells that have been described: their origins in embryonic and adult tissues and their differentiation potential in vivo…

Genome-wide microarray evidence

Purpose To understand cell cycle controls in the 8-Cell human blastomere. Methods Data from whole human genome (43,377 elements) microarray analyses of RNAs from normal 8-Cell human embryos were compiled with published microarrays of RNAs from human fibroblasts, before and after induced pluripo- tency, and embryonic stem cells. A sub database of 3,803 genes identified…

Evidence that human blastomere cleavage is under unique cell cycle control

PURPOSE: To understand the molecular pathways that control early human embryo development. METHODS: Improved methods of linear amplification of mRNAs and whole human genome microarray analyses were utilized to characterize gene expression in normal appearing 8-Cell human embryos, in comparison with published micro-arrays of human fibroblasts and pluripotent stem cells. RESULTS: Many genes involved in…

Detection and identification of bacterial DNA in semen

Objective: To detect and identify bacteria in semen by sequencing polymerase chain reaction (PCR)–amplified ribosomal RNA gene regions (rDNAs). Design: BacterialrDNAsweredetectedbyPCRamplificationofsemenDNA.Conditionswereadjustedtodetect only abundant organisms, no fewer than 20,000 bacteria/mL of semen. Setting: Clinical andrology laboratory and academic research laboratories. Patient(s): Men undergoing fertility evaluation (n 1⁄4 29) or vasectomy (n 1⁄4 5). MainOutcomeMeaure(s): FrequencyofbacterialrDNA–positivespecimens,relationshipofrDNAstobacteriain GenBank,…

Human parthenogenetic blastocysts derived from noninseminated cryopreserved human oocytes

Objective: To report on the development of human parthenogenetic blastocysts and an in vitro attachment that was generated from noninseminated cryopreserved human oocytes for the first time. Design: Prospective study. Setting: Department of reproductive medicine in a medical institute in Buenos Aires, Argentina. Patient(s): Five healthy fertile donors. Intervention(s): Artificial activation of noninseminated cryopreserved human…

Human parthenogenetic blastocysts derived from noninseminated cryopreserved human oocytes

Department of Reproductive Medicine, CER Medical Institute, School of Medicine, Buenos Aires University, Buenos Aires, Argentina. OBJECTIVE: To report on the development of human parthenogenetic blastocysts and an in vitro attachment that was generated from noninseminated cryopreserved human oocytes for the first time. DESIGN: Prospective study. SETTING: Department of reproductive medicine in a medical institute…

Overview Brochure

Bedford Research Foundation is rapidly advancing biomedical research. A Massachusetts public charity, it is setting the standard for ethical and scientific progress in human embryonic stem cell research.

Human Egg Donor Program Resumes… 1st in the Nation

New funding announced today will allow the Bedford Stem Cell Research Foundation near Boston, Massachusetts, to resume its stem cell research on unfertilized human eggs, the first such program in the United States. The research has been interrupted four times because of lack of funding.

What is an Embryo?

Most scientific and medical advances are accompanied by new terms to describe the new processes. Unfortunately, that has not happened with the new tasks eggs are being asked to perform. As a consequence, the term embryo has been mistakenly applied to all forms of activated eggs, and that is causing rancorous debate. The biology of…