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Fall 2014 Newsletter: Breakthroughs in Understanding Circadian Rhythms in Stem Cells

Bedford Research scientists are following up on their discovery that stem cells have a circadian rhythm that may need to be supported for optimum development in the laboratory. In the body, the daily pattern of light and dark controls many signals sent out by the brain, such as those that trigger changes in body temperature,…

Cytomegalovirus and human immunodeficiency virus in semen of homosexual men

Objective: To assess the accuracy of serology to predict the presence of cytomegalovirus (CMV) in semen of homosexual men without and with HIV coinfection. Results: Cytomegalovirus was detected by electron microscopy in 3 of 10 specimens examined. Forty-six (89%) of 52 HIV-infected men were seropositive for CMV by combined assay for IgG/IgM; two more (48…

2013 Newsletter: “Off-the-shelf” Engineered Stem Cells: Are They Therapeutically Valuable?

FROM THE DIRECTOR The astounding 2013 report by an Oregon research team of the successful creation of stem cells from a somatic cell nucleus transferred into an unfertilized human egg was met with surprising calm by the lay press and the bioethics community. This is in sharp contrast to the outcry a decade ago when…

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

Reprogramming somatic cells into pluripotent em- bryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)- ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to pro- duce human NT-ESCs have failed secondary to early embryonic arrest of SCNT…

2012 Newsletter: Four Years of the Spinal Cord Workshop

Since 2008, the Spinal Cord Workshop has brought together international leaders in surgery and basic science to debate and develop a list of the challenges to cures for spinal cord injury. The goal of the workshop is to develop a “white paper,” listing the obstacles. The workshop has brought to light such problems as how…

2011 Newsletter: Progress in Circadian Rhythms And Stem Cells

BRF scientists have derived two unique lines of stem cells that may lead to a breakthrough in the efficiency of stem cell derivation and expansion. BRF scientists are following up their discovery that the genes that regulate the rhythms of daily life, circadian rhythm genes, may play important roles in stem cell derivation and stability…

Human oocytes reprogram somatic cells to a pluripotent state

The exchange of the oocyte’s genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient’s genome, might be useful for cell replacement. Here we report that the development of human oocytes after…

The First Five Days of a Mouse in GEM, Protein-Free Culture Medium

Foundation scientists are deriving new stem cell lines from fertilized mouse eggs in fully defined, protein-free culture medium, GEM (Gamete Embryo Medium). GEM is a specialized fluid that simulates fluids in the womb. The goal of these experiments is to improve the efficiency of deriving new stem cell lines from testis biopsies. By studying time lapse videos of…

2010 Newsletter: The Testis: a source of stem cells for all men?

Could the newly discovered “testis stem cells” be as versatile as embryonic stem cells? Bedford is launching a major research initiative to find out. A major barrier to progress in stem cell therapies is that, similar to organ transplantation, the body rejects cells that are not a good match for the patient. Surprisingly, stem cells…

The therapeutic potential of stem cells

In recent years, there has been an explosion of interest in stem cells, not just within the scientific and medical communities but also among politicians, religious groups and ethicists. Here, we summarize the different types of stem cells that have been described: their origins in embryonic and adult tissues and their differentiation potential in vivo…

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